HackerNews Summary (2023-05-10 12AM)

Source:

Summary
A GitHub repository for the code. Users can append a neon.tech PostgreSQL connection string as the # hash part of the URL to follow along with a simple PostgreSQL session.

Facts

🔗 The code is available on GitHub.

🐘 Users can follow along with a simple PostgreSQL session by appending the neon.tech PostgreSQL connection string as the # hash part of the URL.

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Source: *Punctuation Personified* (1824)

Summary
Punctuation Personified offers guidelines to teach kids the use of punctuation marks in writing. The book also provides instructions for translating these marks into spoken language. Before the standardization of punctuation, printers used to punctuate manuscripts in their way.

Fact

📚 Punctuation Personified aimed to systematize the use of punctuation from an early age.

🧑‍🏫 Printers used to punctuate manuscripts in their ways before the standardization of punctuation.

✍️ Authors of the book aimed to create a unified way of using punctuation in writing.

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Source: 50 years in filesystems: 1984

Summary
In 1984, a group of researchers wrote a paper on an improved Unix filesystem for the 4.3BSD operating system, with promises of better allocation and locality of reference. Different workstation systems of the time had varying CPU architectures and memory sizes.

Fact

📈 The 1984 paper promised better I/O speed and higher throughput for the new Unix filesystem implementation.

🕸️ The original Unix filesystem had structural problems keeping up with file size, number of files, and I/O speed, according to the paper.

💾 Workstations in 1984 had main memory sizes in the low two-digit MB range and two-digit MHz system clocks.

🔍 The paper also mentions the segregation of filesystem metadata at the front of the disk to improve disk subsystems performance.

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Source: Detailed image of the human retina

Summary
Researchers have developed a specialised atlas that aims to map different tissue types and structures in the human body, including organoids. Organoids are clumps of tissue that are developed in a way similar to human organs, but on a small scale. The researchers used a new imaging technique called iterative indirect immunofluorescence imaging (4i) to visualise proteins in the organoids of the human retina, to gather and compile a great deal of information about their development.

Fact

🧬 The researchers have developed an atlas to map different tissue types and structures in the human body, including organoids.

🔬 Organoids are three-dimensional clumps of tissue that are developed in a way similar to human organs, but on a small scale.

👁️ The researchers used iterative indirect immunofluorescence imaging (4i) to visualise several dozen proteins in a thin tissue section at high resolution using fluorescence microscopy.

💊 Organoids can be used to test active substances and learn more about healthy tissue as well as diseases.

🧑‍🔬 The research team applied their approach to the organoids of the human retina, which they derived from stem cells.

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